Naprosyn-Plus® 375/20 mg

Naprosyn-Plus® 375/20 mg

Naprosyn-Plus® 375/20 Tablet: Each tablet contains delayed release Naproxen USP 375 mg & immediate release Esomeprazole Magnesium USP equivalent to Esomeprazole 20 mg. Naprosyn-Plus® 500/20 Tablet: Each tablet contains delayed release Naproxen USP 500 mg & immediate release Esomeprazole Magnesium USP equivalent to Esomeprazole 20 mg.

Naprosyn-Plus® Consists of an immediate release Esomeprazole Magnesium layer & an enteric coated Naproxen core. As a result Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine. Naproxen is a NSAID with analgesic & antipyretic properties. The mechanism of action of Naproxen is to inhibit the prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ –ATP ase in the gastric parietal cell by acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

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